What Does Herpes Do To Your Brain?
Abstract. The development of the inflammatory response within the brain, meninges and cerebrospinal fluid (CSF) compartment has been studied for the first time simultaneously in experimental herpes simplex virus (HSV) encephalitis after inoculation via the cornea. Two major viral pathways were found from the eye to the brain: one through the trigeminal nerve to the brain stem and one through the . Typically, the virus is initially present in a part of the brain called the limbic cortex. It may then spread to the adjacent frontal and temporal lobes of the brain. It is the destruction of tissue in these areas together with brain swelling from the inflammation, which causes many of the symptoms.
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. The HPO collects information on symptoms that have been described in medical resources.
The Bdain is updated regularly. Learn more orphan products. Related diseases are conditions that have similar signs and symptoms. A health care provider how to block outside noise consider these conditions in the table below when making a diagnosis.
Please note that the table may not include all the possible conditions related to this disease. Research helps us better understand brin and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research hos ways to get involved. Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services.
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You can herps advance rare disease research! Other Names:. Summary Summary. Symptoms Symptoms. Showing of 27 View All. Low blood sodium levels. Elevated white blood count. High white blood count. Increased blood leukocyte number. Passing out. Speech disorder. Dows impairment. Speech impediment. Increased blood neutrophil counts. Swelling of brain. Tk daytime sleepiness. More than typical sleepiness during day.
Increased reflexes. Low glucose levels in cerebral spinal fluid. Decreased immune xpread. Repeated seizures without recovery between them. Do you have more information about symptoms of this disease? We want to hear from you. Do you dies updated information on this disease? Treatment Treatment. Related Diseases Related Diseases. Conditions with similar signs and symptoms from Orphanet.
Differential diagnosis includes: other viral causes of encephalitis, varicella zoster virus, enteroviruses etc ; bacterial infections, including ricketsial disease, mycoplasma pneumonia, chlamydophila infections; autoimmune diseases, such as paraneoplastic limbic encephalitis, acute disseminated encephalomyelitis, Rasmussen subacute encephalitis; and other causes including space occupying lesion and non-infectious encephalopathy. Visit the Orphanet disease page for more information.
Research Research. Clinical Research Resources ClinicalTrials. Click on the link to go sspread ClinicalTrials. Please note: Studies listed on the ClinicalTrials. We strongly recommend that you talk with a trusted healthcare provider before choosing to participate in any clinical study. Organizations Organizations. Organizations Supporting this Disease.
Do you know of an organization? Learn More Learn More. Click on the link to view information on this topic. NORD is a patient advocacy organization how to use tousle me softly products individuals sread rare diseases and the organizations that serve them.
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Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge. PubMed is a searchable database of medical literature and lists journal articles that discuss Herpes simplex encephalitis. Click on the link to view a sample search on this topic.
Have a brani References References. Anderson WE. Herpes Simplex Encephalitis. Medscape Reference. Klein RS. Herpes simplex virus type herpez encephalitis. Do you know sptead a review article? What to do if you did not receive your w- 2 this content:. Close Copy Link. You May Be Interested In. How to Find a Disease Specialist.
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Finding Funding Opportunities. Teaching Resources. EEG spreav. Tired Tiredness [ more ]. Increased CSF protein. Elevated white blood count High white blood count Increased blood leukocyte number [ more ].
Speech disorder Speech impairment Speech impediment [ more ]. Excessive daytime sleepiness More than hoa sleepiness during day [ more ].
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General Discussion. Herpes simplex encephalitis (HSE) is a rare neurological disorder characterized by inflammation of the brain (encephalitis). Common symptoms include headaches, fevers, drowsiness, hyperactivity, and/or general weakness. The disorder may have some symptoms similar to those associated with meningitis, such as a stiff neck, altered reflexes, confusion, and/or speech abnormalities.
The development of the inflammatory response within the brain, meninges and cerebrospinal fluid CSF compartment has been studied for the first time simultaneously in experimental herpes simplex virus HSV encephalitis after inoculation via the cornea. Two major viral pathways were found from the eye to the brain: one through the trigeminal nerve to the brain stem and one through the nasolacrimal duct to the olfactory system. Viral antigen was found to be present in the CNS before there were clinical signs or cellular infiltration of brain tissue.
Subsequently, the virus spread to all parts of the trigeminal brain stem complex. This phenomenon was accompanied by severe inflammation of the meninges covering the trigeminal root near its entry into the brain stem. The meninges near the entry of the olfactory fila also contained antigen. However, HSV-1 did not spread along meningeal rami of the trigeminal nerve and, consequently, is--at least in this experimental model--not a route to reach the inferior frontal and temporal lobes.
The development of CSF changes followed the histopathological development of meningitis and encephalitis closely. We postulate that HSV is carried to the CSF by infected leukocytes rather than a direct spread to the CSF by simple extension of the encephalitic process to the meningeal surface. Abstract The development of the inflammatory response within the brain, meninges and cerebrospinal fluid CSF compartment has been studied for the first time simultaneously in experimental herpes simplex virus HSV encephalitis after inoculation via the cornea.
Publication types Research Support, Non-U. Substances Antigens, Viral.